PHYSIOLOGICAL AND PHARMACOLOGICAL STUDIES ON COAL TAR COLORS

Coal tars and coal tar pitches.

Numerous studies, mostly case reports, have found that occupational exposure to coal tars or coal-tar pitches (coal-tar distillates) is associated with skin cancer, including scrotal cancer; workers in these studies have included patent-fuel (coal-briquette) workers, pitch loaders, workers in electrical trades, and optical-lens polishers (IARC 1985, 1987). A 1946 study in the United Kingdom fou...

Cold Applied Coal Tar Paints

Physiological and Pharmacological Studies of Magnesium Salts

I n t r o d u c t o r y . T h e narcotic effect as well as the toxicity of magnesium salts, when introduced subcutaneously, depend to a great degree upon the readiness with which they are eliminated from the body. By what path are these salts eliminated? Are they excreted by the intestinal canal or are they eliminated through the kidneys? Meltzer and Auer" state that from their experiments they...

Studies on the toxicity of coal-tar dyes. III. Reason of acute toxicity to fish caused by coal-tar dyes and their industrial effluents.

Reason of acute toxicity to fish caused by coal-tar dyes and their industrial effluents were studied from the three points of view. 1) Partition coefficient (n-octanol/water) was determined on several coal-tar dyes, and it was found that the larger the ratio was, the stronger was toxicity to fish. 2) As a result of determination about existent form of xanthene dyes under photo-irradiation, it w...

Electrophysiological, pharmacological and behavioral studies of different physiological roles of the nucleus paragigantocellularis

The nucleus paragigantocellularis (PGI) is located in the rostral ventrolateral medulla and has noticeable connections with some other brain nuclei, such as locus ceruleus, nucleus raphe magnus and periaqueductal gray. In rats it is 3 mm in rostrocaudal and 1 mm in mediolateral and 1 mm in the dorsolateral aspect. Anatomically and functionally, PGI has been divided into two subnuclei, retrofaci...